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Literature summary for 2.3.1.48 extracted from
- The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila (2010), J. Neurochem., 115, 493-504.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VQZ6 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| elongator protein 3 | catalytic subunit of the elongator complex | Drosophila melanogaster |
| ELP3 | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | targeted reduction of ELP3 specifically in the developing Drosophila nervous system leads to a hyperactive phenotype with increase in climbing and locomotor activities and sleep loss in the adult flies, a significant expansion in synaptic bouton number and axonal length and branching in the larval neuromuscular junction as well as the misregulation of genes involved in sleep, vesicle transport and fusion, and protein chaperone activity. Ubiquitous reduction of ELP3 results in lethality | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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