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Literature summary for 2.3.1.48 extracted from

  • Zhao, H.; Jin, S.; Gewirtz, A.M.
    The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia (2012), J. Biol. Chem., 287, 925-934.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine expression of isoform Tip60 is about 60% lower in samples from patients with acute myeloid leukemia Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
More enzyme interacts with c-Myb, the interaction is dependent on the isoform TIP60 acetyltransferase domain and c-Myb transactivation domain Homo sapiens

Synonyms

Synonyms Comment Organism
Tip60
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function coexpressing isoform TIP60 decreases the transcriptional activation ability of c-Myb in functional reporter assays. TIP60 binds to the c-Myb target gene c-Myc promoter in a c-Myb-dependent manner. Knockdown of isoform Tip60 expression by siRNA increases endogenous c-Myc expression. c-Myb is associated with histone deacetylases HDAC1 and HDAC2, known to interact with TIP60 and repress transcription Homo sapiens