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Literature summary for 2.3.1.48 extracted from

  • Li, Y.; Jaramillo-Lambert, A.; Hao, J.; Yang, Y.; Zhu, W.
    The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase (2011), J. Biol. Chem., 286, 41344-41352.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
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 Homo sapiens
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HEK-293T cell
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 Homo sapiens
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HeLa cell
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 Homo sapiens
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U2-OS cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Gcn5
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 Homo sapiens
general control non-derepressible 5
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 Homo sapiens

General Information

General Information Comment Organism
metabolism the ablation of Cullin4-RING E3 ubiquitin ligase CRL4 leads to the stabilization of isoform Gcn5 in cells with depleted And-1, and Cdc10-dependent transcript 2, i.e. Cdt2, serves as a substrate receptor protein of CRL4. Overexpression of Cdt2 reduces the isoform Gcn5 protein levels, and CRLCdt2 is sufficient to ubiquitinate Gcn5 both in vivo and in vitro. And-1 stabilizes Gcn5 by impairing the interaction between Gcn5 and CRLCdt2 and thereby preventing Gcn5 ubiquitination and degradation. The degradation of Gcn5 is not dependent on proliferating cell nuclear antigen Homo sapiens