Cloned (Comment) | Organism |
---|---|
overexpression of recombinant histone acetyltransferase domain of p300/CBP-associated factor, residues 157657, in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-methoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | antiproliferative effects in cancer cells, GI50 value 0.007 mM with SK-N-SH cell | Homo sapiens | |
2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one | antiproliferative effects in cancer cells, GI50 value 0.0005 mM with SK-N-SH cell, 0.030 mM with MCF-7 cell | Homo sapiens | |
2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | antiproliferative effects in cancer cells, GI50 value 0.010 mM with SK-N-SH cell, 0.037 mM with MCF-7 cell | Homo sapiens | |
2-(4-methylphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | antiproliferative effects in cancer cells, GI50 value 0.006 mM with SK-N-SH cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 peptide | residues 1-21 of human histone H3 | Homo sapiens | CoA + actylhistone H3 | - |
? | |
acetyl-CoA + histone H4 peptide | residues 2-24 of human histone H4 | Homo sapiens | CoA + actylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P300/CBP-associated factor | - |
Homo sapiens |
PCAF | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00072 | - |
substrate histone H4 peptide, pH 7.5, 30°C | Homo sapiens | 2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | |
0.00164 | - |
substrate histone H3 peptide, pH 7.5, 30°C | Homo sapiens | 2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | |
0.00463 | - |
substrate histone H3 peptide, pH 7.5, 30°C | Homo sapiens | 2-(4-methylphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | |
0.00503 | - |
substrate histone H3 peptide, pH 7.5, 30°C | Homo sapiens | 2-(3-methoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one | |
0.0255 | - |
substrate histone H3 peptide, pH 7.5, 30°C | Homo sapiens | 2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one | |
0.13 | - |
substrate histone H3 peptide, pH 7.5, 30°C | Homo sapiens | 2-(4-(trifluoromethyl)benzyl)isothiazolo[5,4-b]pyridin-3(2H)-one |