Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a unique target for therapeutic antifungal compounds | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of Rtt109 in the clinical isolate SC5314. rtt109-/- mutant cells lack acetylated H3K56 and are hypersensitive to genotoxic agents. Additionally, rtt109-/- mutant cells constitutively display increased H2A S129 phosphorylation and elevated DNA repair gene expression, consistent with endogenous DNA damage. Importantly, rtt109-/- mutant cells are significantly less pathogenic in BALB/cByJ mice and more susceptible to killing by macrophages in vitro than are wild-type cells, phenotype, overview. rtt109-/- mutant cells display an altered profile of metabolic gene expression compared to the wild-type and constitutively induce DNA repair genes, transcription profile, overview | Candida albicans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Candida albicans | acetylation of Lys56 | CoA + acetylhistone H3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
clinical isolate SC5314, ORF19.7491 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation of Lys56 | Candida albicans | CoA + acetylhistone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rtt109 | fungal-specific histone acetyltransferase | Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
physiological function | Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity, and Rtt109 is particularly important for fungal pathogenicity | Candida albicans |