Any feedback?
Literature summary for 2.3.1.48 extracted from
- CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain (2010), Dev. Cell, 18, 114-125.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | neonatal cbp+/- mice are behaviourally impaired and display perturbed vocalization behaviour. Knockdown of CBP by siRNA causes a reduction in betaII-tubulin-positive neurons, and inhibits neurogenesis and gliogenesis, cell phenotype, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H3 | Mus musculus | CBP binds and acetylates histones at neural promoters, and regulates Corpus Callosum development. CBP binds to neuronal and glial promoters and globally promotes histone acetylation in the embryonic cortex, e.g. the beta-actin promoter, overview | CoA + acetylhistone H3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
gene cbp | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | CBP phosphorylation at Ser436 by atypical protein kinase zeta is necessary for histone acetylation at neural gene promoters and appropriate differentiation | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | cortex, CBP is expressed throughout embryogenesis, enzyme levels are decreasing postnatally | Mus musculus | - |
| glia cell | in the embryonic cortex, nestin-positive precursors and betaII-tubulin positive neurons from E12-E13 primary cortical precursor cell culture | Mus musculus | - |
| neural stem cell | e.g. GFAP-positive astrocyytes and A2B5-positive oligodendrocyte precursors | Mus musculus | - |
| neuron | the embryonic cortex, nestin-positive precursors and betaII-tubulin positive neurons from E12-E13 primary cortical precursor cell culture | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H3 | CBP binds and acetylates histones at neural promoters, and regulates Corpus Callosum development. CBP binds to neuronal and glial promoters and globally promotes histone acetylation in the embryonic cortex, e.g. the beta-actin promoter, overview | Mus musculus | CoA + acetylhistone H3 | - |
? | |
| acetyl-CoA + histone H3 | acetylation of Lys9 and Lys14 | Mus musculus | CoA + acetylhistone H3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cbp | - |
Mus musculus |
| CBP histone acetyltransferase | - |
Mus musculus |
| CREB binding protein | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the haploinsufficient enzyme causes the Rubinstein-Taybi syndrome, a genetic disorder with cognitive dysfunction, by disrupting the control mechanism of neural precursor competency to differentiate | Mus musculus |
| physiological function | CBP regulates neurobehavioural development, the enzyme activity and histone acetylation is required for control of neural cortical precursor competency to differentiate, regulation via environmental factors | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
