Cloned (Comment) | Organism |
---|---|
real-time RT-PCR analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA transfection: down-regulation of Tip60 and DNMT1 by RNA interference, dramatically reduced the levels of acetylated H2AK5 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | although downregulation of UHRF1 by RNA interference enhances Tip60 expression, a significant decrease of the level of acetylated H2AK5 is observed | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H2A | Homo sapiens | acetylation at Lys5 by Tip60 | CoA + acetylhistone H2A | - |
? | |
additional information | Homo sapiens | Tip60 is part of the evolutionarily conserved NuA4 complex | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | Tip60 co-localizes with the UHRF1/DNMT1 complex | Homo sapiens | - |
additional information | Tip60 is part of the evolutionarily conserved NuA4 complex | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H2A | acetylation at Lys5 by Tip60 | Homo sapiens | CoA + acetylhistone H2A | - |
? | |
additional information | Tip60 is part of the evolutionarily conserved NuA4 complex | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tat-interactive protein, 60 kDa | - |
Homo sapiens |
Tip60 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | down-regulation of Tip60 and DNMT1 by RNA interference, dramatically reduced the levels of acetylated H2AK5 | down |
Homo sapiens | although downregulation of UHRF1 by RNA interference enhances Tip60 expression, a significant decrease of the level of acetylated H2AK5 is observed | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Tip60 plays multiple roles in chromatin remodeling processes. Tip60 is a partner of the epigenetic integration platform interplayed by UHRF1, DNMT1 and HDAC1 involved in the epigenetic code replication | Homo sapiens |