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Literature summary for 2.3.1.48 extracted from

  • Achour, M.; Fuhrmann, G.; Alhosin, M.; Ronde, P.; Chataigneau, T.; Mousli, M.; Schini-Kerth, V.B.; Bronner, C.
    UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity (2009), Biochem. Biophys. Res. Commun., 390, 523-528.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
real-time RT-PCR analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA transfection: down-regulation of Tip60 and DNMT1 by RNA interference, dramatically reduced the levels of acetylated H2AK5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information although downregulation of UHRF1 by RNA interference enhances Tip60 expression, a significant decrease of the level of acetylated H2AK5 is observed Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H2A Homo sapiens acetylation at Lys5 by Tip60 CoA + acetylhistone H2A
-
?
additional information Homo sapiens Tip60 is part of the evolutionarily conserved NuA4 complex ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell Tip60 co-localizes with the UHRF1/DNMT1 complex Homo sapiens
-
additional information Tip60 is part of the evolutionarily conserved NuA4 complex Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H2A acetylation at Lys5 by Tip60 Homo sapiens CoA + acetylhistone H2A
-
?
additional information Tip60 is part of the evolutionarily conserved NuA4 complex Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Tat-interactive protein, 60 kDa
-
Homo sapiens
Tip60
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens down-regulation of Tip60 and DNMT1 by RNA interference, dramatically reduced the levels of acetylated H2AK5 down
Homo sapiens although downregulation of UHRF1 by RNA interference enhances Tip60 expression, a significant decrease of the level of acetylated H2AK5 is observed up

General Information

General Information Comment Organism
physiological function Tip60 plays multiple roles in chromatin remodeling processes. Tip60 is a partner of the epigenetic integration platform interplayed by UHRF1, DNMT1 and HDAC1 involved in the epigenetic code replication Homo sapiens