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Literature summary for 2.3.1.48 extracted from

  • Barman, H.K.; Takami, Y.; Nishijima, H.; Shibahara, K.; Sanematsu, F.; Nakayama, T.
    Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex (2008), Biochem. Biophys. Res. Commun., 373, 624-630.
    View publication on PubMed
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information loss of HAT1 causes mild growth defects and increases sensitivities to methyl methanesulfonate and camptothecin. Stable expression of tagged Asf1 and C-terminally HA-Flag-tagged histone H4 in enzyme-deficient DT40 HAT-/- cells. Cytosolic Hat1-RbAp48 associate with histones H3 and H4, and Asf1 in vivo Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic Hat1-RbAp48 associate with histones H3 and H4, and Asf1 in vivo Gallus gallus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Gallus gallus
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 CoA + acetylhistone H3
-
 ?
acetyl-CoA + histone H4 Gallus gallus Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol CoA + acetylhistone H4
-
 ?
additional information Gallus gallus histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
DT-40 cell
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 Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3
-
 Gallus gallus CoA + acetylhistone H3
-
 ?
acetyl-CoA + histone H4
-
 Gallus gallus CoA + acetylhistone H4
-
 ?
acetyl-CoA + histone H4 Hat1 is a primary enzyme for di-acetylating cytosolic histone H4 at Lys5 and Lys12 in the cytosol Gallus gallus CoA + acetylhistone H4
-
 ?
additional information histones H3 and H4 and their chaperone Asf1, including RbAp48, a regulatory subunit of Hat1 enzyme, are associated with Hat1 in the cytosol of chicken cells. Hat1 regulates integrity of cytosolic histone H3-H4 containing complex, effect of Hat1 on status for the cytosolic histones H3/H4 pre-deposition complexes with respective chaperone proteins, overview Gallus gallus ?
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 ?

Synonyms

Synonyms Comment Organism
Hat1
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 Gallus gallus
histone acetyltransferase-1
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 Gallus gallus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Gallus gallus