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Literature summary for 2.3.1.48 extracted from
- Characterization of the yeast trimeric-SAS acetyltransferase complex (2005), J. Biol. Chem., 280, 11987-11994.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis | Saccharomyces cerevisiae |
| 44000 | - |
1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis | Saccharomyces cerevisiae |
| 75000 | - |
1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis | Saccharomyces cerevisiae |
| 125000 | - |
- |
Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | Saccharomyces cerevisiae | exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae | CoA + acetylhistone H4 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | exclusively acetylates of Lys16 of histone H4, the enzyme is required for bulk of H4 lysine 16 acetylation in vivo, role of SAS complex in antagonizing the speading of Sir proteins at silent loci in Saccharomyces cerevisiae | Saccharomyces cerevisiae | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | acetyltion of Lys16, acetylates free histones and weakly acetylates nucleosomes | Saccharomyces cerevisiae | CoA + acetylhistone H4 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 1 * 44000 + 1 * 75000 + 1 * 29000, the SAS complex consists of Sas2, Sas4 and Sas5, mass spectrometry analysis | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SAS complex | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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