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Literature summary for 2.3.1.48 extracted from
- Porcine liver nuclear histone acetyltransferase. Partial purification and basic properties (1984), J. Biol. Chem., 259, 3413-3419.
General Stability
| General Stability | Organism |
|---|---|
| glycerol protects against thermal denaturation at 37°C | Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | - |
Sus scrofa |  |
| K+ | 175 mM: 50% inhibition | Sus scrofa | |
| Mg2+ | 37 mM: 50% inhibition | Sus scrofa | |
| N-ethylmaleimide | - |
Sus scrofa | |
| Na+ | 160 mM: 50% inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Sus scrofa |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Sus scrofa | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 94000 | - |
gel filtration, glycerol gradient ultracentrifugation | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Sus scrofa | CoA + acetylhistone | - |
? | |
| acetyl-CoA + histone | chymostatic peptides of histones | Sus scrofa | CoA + acetylhistone | - |
? | |
| acetyl-CoA + histone H3 | histone H3: preferred substrate | Sus scrofa | CoA + acetylhistone H3 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
glycerol protects against thermal denaturation at 37°C | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
| 7.5 | - |
- |
Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 8.4 | about 50% of activity maximum at pH 6.6 and pH 8.4 | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 175 | - |
K+ | - |
Sus scrofa | |
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