Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DNA | in vitro, enzyme form A inhibited, enzyme form B relatively insensitive | Rattus norvegicus | |
EDTA | high concentrations | Rattus norvegicus | |
histone | inhibits spermidine acetylation, enzyme forms A and B | Rattus norvegicus | |
spermidine | inhibits histone acetylation at high concentrations, enzyme forms A and B | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
acetyl-CoA | + spermidine, enzyme form B | Rattus norvegicus | |
0.015 | - |
acetyl-CoA | + spermidine, enzyme form A | Rattus norvegicus | |
0.18 | - |
spermidine | enzyme form B | Rattus norvegicus | |
0.27 | - |
spermidine | enzyme form A | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | enzyme form A and B | Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
2 enzyme forms: A and B | - |
Purification (Comment) | Organism |
---|---|
partial, enzyme forms A and B | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00186 | - |
enzyme form B | Rattus norvegicus |
0.00196 | - |
enzyme form A | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 1,4-butanediamine | enzyme form A and B, low activity | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + 1,4-butanediamine | i.e. putrescine | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + 1,5-pentanediamine | enzyme form A and B, low activity | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + 1,5-pentanediamine | i.e. cadaverine | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + 1,6-hexanediamine | enzyme form A shows low activity , B not | Rattus norvegicus | ? | - |
? | |
acetyl-CoA + histone | histone H1 poor substrate | Rattus norvegicus | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H1 | histone H1 poor substrate | Rattus norvegicus | CoA + acetylhistone H1 | - |
? | |
acetyl-CoA + histone H3 | histone H3: preferred substrate | Rattus norvegicus | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | histone H4 is a poor substrate | Rattus norvegicus | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + spermidine | - |
Rattus norvegicus | ? | - |
? | |
acetyl-CoA + spermine | - |
Rattus norvegicus | ? | - |
? | |
additional information | diaminodipropylamine and 1,3-propanediamine are no substrates | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
enzyme form B, substrate histone | Rattus norvegicus |
7.8 | 8.8 | enzyme form B, substrate spermidine | Rattus norvegicus |
8.5 | 8.8 | enzyme form A, substrate spermidine | Rattus norvegicus |
8.8 | - |
enzyme form A, substrate histine | Rattus norvegicus |