Literature summary for 2.3.1.47 extracted from

Hahn, H.G.; Choi, J.S.; Lim, H.K.; Lee, K.I.; Hwang, I.T.
Triazolyl phenyl disulfides: 8-amino-7-oxononanoate synthase inhibitors as potential herbicides (2015), Pestic. Biochem. Physiol., 125, 78-83.

Search for more literature for 2.3.1.47

Application

Application	Comment	Organism
agriculture	8-amino-7-oxononanoate synthase triazolyl phenyl disulfide inhibitors as potential herbicides, overview	Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment)	Organism
gene bioF, recombinant expression of the enzyme in Escherichia coli strain BL21-Gold (DE)	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
3-([4-[(2-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
3-([4-[(3,5-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide	-	Arabidopsis thaliana
additional information	triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview	Arabidopsis thaliana
N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide	i.e. KHG23844, induces 2.3fold higher L-alanine accumulation in the treated Arabidopsis thaliana plants. 45-day old Arabidopsis thaliana plants are completely killed by the compound. Foliar supplement of 1 mM biotin at 1 and 2 days before KHG23844 application effectively recovers the growth inhibition of plants treated with the inhibitor	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pimeloyl-[acyl-carrier protein] + L-alanine	Arabidopsis thaliana	-	8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q8GW43	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme from Escherichia coli strain BL21-Gold (DE)	Arabidopsis thaliana

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pimeloyl-[acyl-carrier protein] + L-alanine	-	Arabidopsis thaliana	8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
7-keto-8-aminopelargonate synthase	-	Arabidopsis thaliana
AONS	-	Arabidopsis thaliana
KAPAS	-	Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Arabidopsis thaliana

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Arabidopsis thaliana

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.037	-	pH 7.5, 30°C, recombinant enzyme	Arabidopsis thaliana	3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide
0.055	-	pH 7.5, 30°C, recombinant enzyme	Arabidopsis thaliana	3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
0.063	-	pH 7.5, 30°C, recombinant enzyme	Arabidopsis thaliana	N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide
0.07	-	pH 7.5, 30°C, recombinant enzyme	Arabidopsis thaliana	3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide
0.073	-	pH 7.5, 30°C, recombinant enzyme	Arabidopsis thaliana	3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide

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Release 2023.1 (January 2023)