Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.46 extracted from

  • Tang, X.L.; Chen, L.J.; Du, X.Y.; Zhang, B.; Liu, Z.Q.; Zheng, Y.G.
    Regulation of homoserine O-succinyltransferase for efficient production of L-methionine in engineered Escherichia coli (2020), J. Biotechnol., 309, 53-58 .
    View publication on PubMed
Search for more literature for 2.3.1.46

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain DELTAIJA Escherichia coli

Protein Variants

Protein Variants Comment Organism
A28V the mutation leads to 2.94fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
I296S the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
L63F the mutation leads to 2.91fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
L63F/A28V the mutations lead to 4.3fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
N267D the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
P298L the mutation leads to 2.89fold improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
Q64E the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
R27C the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli
S61T the mutation leads to improved L-methionine productivity in Escherichia coli DELTAIJA strain Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + L-homoserine Escherichia coli
-
 CoA + O-succinyl-L-homoserine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P07623
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + L-homoserine
-
 Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?

Synonyms

Synonyms Comment Organism
MetA
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the initial step of L-methionine biosynthesis. Enzyme overexpression results in obviously improved L-methionine yield in Escherichia coli DELTAIJA strain Escherichia coli