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Literature summary for 2.3.1.46 extracted from

  • Mares, R.; Urbanowski, M.L.; Stauffer, G.V.
    Regulation of the Salmonella typhimurium metA gene by the metR protein and homocysteine (1992), J. Bacteriol., 174, 390-397.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.46

Cloned(Commentary)

Cloned (Comment) Organism
metA gene, expression in Escherichia coli auxotrophic strains as lacZ fusion proteins Salmonella enterica subsp. enterica serovar Typhimurium
metA gene, expression in Escherichia coli auxotrophic strains as lacZ fusion proteins Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
D-methionine slight feed-back inhibition Escherichia coli
D-methionine slight feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium
L-methionine feed-back inhibition Escherichia coli
L-methionine feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + L-homoserine Salmonella enterica subsp. enterica serovar Typhimurium
-
 CoA + O-succinyl-L-homoserine
-
 ?
succinyl-CoA + L-homoserine Escherichia coli involved in cystathionine and methionine biosynthesis CoA + O-succinyl-L-homoserine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
 metA gene
-
Escherichia coli
-
 auxotrophic mutants derived from K-12
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
 metA gene
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + L-homoserine
-
 Salmonella enterica subsp. enterica serovar Typhimurium CoA + O-succinyl-L-homoserine
-
 ?
succinyl-CoA + L-homoserine
-
 Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?
succinyl-CoA + L-homoserine involved in cystathionine and methionine biosynthesis Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?