Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | inhibition of transfer to endogenous acceptors, no inhibition of transfer from acetyl intermediate to free acetylneuraminate | Rattus norvegicus | |
diethyl dicarbonate | - |
Rattus norvegicus | |
N-bromosuccinimide | - |
Rattus norvegicus | |
Triton X-100 | above 0.02% | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0028 | - |
acetyl-CoA | cosubstrate glycosidically bound N-acetylneuraminate | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | equally distributed between membrane and cytosolic fraction | Rattus norvegicus | 5829 | - |
Golgi vesicle | equally distributed between membrane and cytosolic fraction | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + sialic acid | Rattus norvegicus | pathway, overview | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate | 7-O-acetyl groups can migrate to the 9-position | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
-70°C, prelabeled Golgi vesicles, 4 days | Rattus norvegicus |
frozen Golgi vesicles are stable for 3-6 months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + N-acetylneuraminate | glycosidically bound N-acetylneuraminate | Rattus norvegicus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + N-acetylneuraminate | acetylneuraminate bound to sialic acids | Rattus norvegicus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + N-acetylneuraminate | free acetylneuraminate | Rattus norvegicus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? | |
acetyl-CoA + sialic acid | pathway, overview | Rattus norvegicus | CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00074 | - |
CoA | - |
Rattus norvegicus |