Activating Compound | Comment | Organism | Structure |
---|---|---|---|
antibody 27C3 | antibody 27C3 binds to and substantially enhances the activity of the enzyme | Macaca fascicularis | |
antibody 27C3 | antibody 27C3 binds to and substantially enhances the activity of the enzyme. 24 h after dosing 27C3, a 2.3fold increase of the serum enzyme enzyme activity is observed, followed by a steady elevation of enzyme activity that is sustained for about 20 days before gradually returning to baseline levels | Homo sapiens | |
additional information | antibody 14F11 does not enhances the enzyme activity | Homo sapiens | |
additional information | antibody 14F11 does not enhances the enzyme activity | Macaca fascicularis |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293S cells | Homo sapiens |
expressed in HEK-293S cells | Macaca fascicularis |
Crystallization (Comment) | Organism |
---|---|
in complex with antibody 27C3, hanging drop vapor diffusion method, using 0.1 M HEPES (pH 7.0) and 5% (w/v) PEG 20000 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C31Y | the mutant has an about 10fold higher cholesterol esterification activity compared with wild type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antibody 25B7 | - |
Homo sapiens | |
antibody 25B7 | - |
Macaca fascicularis | |
additional information | antibody 14F11 does not inhibit the enzyme activity | Homo sapiens | |
additional information | antibody 14F11 does not inhibit the enzyme activity | Macaca fascicularis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04180 | - |
- |
Macaca fascicularis | A0A2K5WDQ7 | - |
- |
Purification (Comment) | Organism |
---|---|
protein A affinity column chromatography, HisTrap column chromatography and Superdex S200 gel filtration | Homo sapiens |
protein A affinity column chromatography, HisTrap column chromatography and Superdex S200 gel filtration | Macaca fascicularis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood plasma | - |
Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alpha-phosphatidylcholine type XVI-E + cholesterol | - |
Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
L-alpha-phosphatidylcholine type XVI-E + cholesterol | - |
Macaca fascicularis | 1-acylglycerophosphocholine + cholesteryl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
LCAT | - |
Macaca fascicularis |
lecithin-cholesterol acyltransferase | - |
Homo sapiens |
lecithin-cholesterol acyltransferase | - |
Macaca fascicularis |