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Literature summary for 2.3.1.43 extracted from

  • Subbaiah, P.V.; Jiang, X.C.; Belikova, N.A.; Aizezi, B.; Huang, Z.H.; Reardon, C.A.
    Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity (2012), Biochim. Biophys. Acta, 1821, 908-913.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.43

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 serine palmitoyltransferase deficient mice, and sphingomyelin synthase deficient mice, both of which have below normal sphingomyelin (SM)/phosphatidylcholine (PC) ratios, show significantly elevated LCAT activities when assayed with the endogenous substrates. LDL receptor knockout mice, and apo E knockout mice, both of which have high SM/PC ratios, have reduced LCAT activities Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information for the endogenous assay, the plasma sample is equilibrated with human serum albumin-3H cholesterol emulsion Mus musculus ?
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 ?
additional information for the exogenous substrate assay, proteoliposomes containing 14C-labeled cholesterol, egg PC, and apo AI at molar ratios of 15:300:1 are prepared. Plasma sample is incubated with proteoliposome substrate Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
LCAT
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 Mus musculus
lecithin/cholesterol acyltransferase
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 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction serine palmitoyltransferase deficient mice, and sphingomyelin synthase deficient mice, both of which have below normal sphingomyelin (SM)/phosphatidylcholine (PC) ratios, show significantly elevated LCAT activities when assayed with the endogenous substrates. LDL receptor knockout mice, and apo E knockout mice, both of which have high SM/PC ratios, have reduced LCAT activities Mus musculus