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Literature summary for 2.3.1.43 extracted from

  • Pavlovic, N.; Orem, W.; Tatu, C.; Lerch, H.; Bunnell, J.; Feder, G.; Kostic, E.; Ordodi, V.
    The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis (2008), Food Chem. Toxicol., 46, 949-954.
    View publication on PubMed
Search for more literature for 2.3.1.43

Inhibitors

Inhibitors Comment Organism Structure
additional information water samples from Balkan endemic nephropathy, BEN, villages from Serbia and Romania show higher LCAT inhibiting activity compared to deionised water and non-endemic water. Inhibitory effect of the organic compounds found in endemic water supplies can cause secondary LCAT deficiency and provide an ethiopathogenic basis for the development of BEN in the susceptible population, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

Synonyms Comment Organism
LCAT
-
 Homo sapiens
lecithin cholesterol acyltransferase
-
 Homo sapiens
plasma lecithin-cholesterol acyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction LCAT inhibition leads to the Balkan endemic nephropathy, BEN, chronic, slowly progressive renal disease, overview. Familial renal disease can develop secondary LCAT deficiency and associated lipid abnormalities Homo sapiens