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Literature summary for 2.3.1.43 extracted from
- Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo (2009), Circulation, 120, 160-169.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| LCAT overexpression in transgenic mouse J774 macrophages | Mus musculus |
| LCAT overexpression in transgenic mouse J774 macrophages | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | LCAT overexpression in transgenic wild-type and human-apolipoprotein A-I-transgenic mice does not promote macrophage reverse cholesterol transport, even in the setting of hepatic SR-BI overexpression or CETP expression, overview | Homo sapiens |
| additional information | overexpression of human LCAT in transgenic wild-type and human-apolipoprotein A-I-transgenic mice does not promote macrophage reverse cholesterol transport, even in the setting of hepatic SR-BI overexpression or CETP expression, overview. LCAT heterozygous and homozygous deficient mice mutants, phenotypes, detailed overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Mus musculus | - |
- |
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + cholesterol | Mus musculus | - |
cholesteryl ester + lysophosphatidylcholine | - |
? |  |
| phosphatidylcholine + cholesterol | Homo sapiens | - |
cholesteryl ester + lysophosphatidylcholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Mus musculus | - |
| blood plasma | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + cholesterol | - |
Mus musculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
| phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? | |
| phosphatidylcholine + cholesterol | LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the 3beta-hydroxy group of free cholesterol | Mus musculus | cholesteryl ester + lysophosphatidylcholine | - |
? | |
| phosphatidylcholine + cholesterol | LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the 3beta-hydroxy group of free cholesterol | Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LCAT | - |
Mus musculus |
| LCAT | - |
Homo sapiens |
| lecithin: cholesterol acyltransferase | - |
Mus musculus |
| lecithin: cholesterol acyltransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | LCAT is a key enzyme in the metabolism of high-density lipoprotein, HDL | Mus musculus |
| physiological function | LCAT is a key enzyme in the metabolism of high-density lipoprotein, HDL. It is responsible for the synthesis of cholesteryl esters in human plasma. In addition to its role in HDL metabolism, LCAT has been proposed to have a critical and central role in reverse cholesterol transport, RCT, the process by which excess peripheral cholesterol is effluxed to HDL-based acceptors and returned to the liver for biliary excretion | Homo sapiens |
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Release 2023.1 (January 2023)
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