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Literature summary for 2.3.1.43 extracted from
- Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate (2006), Biochemistry, 45, 5029-5038.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ceramide | 30% activation, stimulation of synthesis of 20:4 cholesteryl ester and 18:2 cholesteryl ester, but not of 16:0 cholesteryl ester, a phosphocholine ether matrix abolishes the activation effect | Homo sapiens |  |
General Stability
| General Stability | Organism |
|---|---|
| the purified enzyme is instable | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ceramide phosphate | stronger physiologic inhibitory effect compared to sphingomyelin | Homo sapiens | |
| additional information | no inhibition by ceramide | Homo sapiens | |
| sphingomyelin | physiologic inhibitor, ceramide protects partially | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the activity and fatty acid specificity of LCAT may be altered during the inflammatory response | ? | - |
? | |
| phosphatidylcholine + cholesterol | Homo sapiens | - |
1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from plasma | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the activity and fatty acid specificity of LCAT may be altered during the inflammatory response | Homo sapiens | ? | - |
? | |
| additional information | fatty acid specificity of LCAT, overview | Homo sapiens | ? | - |
? | |
| phosphatidylcholine + cholesterol | - |
Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
| phosphatidylcholine + cholesterol | proteoliposome substrates | Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LCAT | - |
Homo sapiens |
| lecithin-cholesterol acyltransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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