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Literature summary for 2.3.1.43 extracted from
- Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K) (1998), J. Biol. Chem., 273, 32561-32567.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein A-I | the naturally occurring mutant T123I is defective in activation by apo A-I | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the naturally occurring mutants T123I and N228K in COS-1 and CHO cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Km for two naturally occurring mutant enzymes | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity of the wild-type and two naturally occurring mutant enzymes | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p-nitrophenol butyrate + H2O | esterase activity | Homo sapiens | p-nitrophenol + butyric acid | - |
? |  |
| phosphatidylcholine + sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
? | |
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