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Literature summary for 2.3.1.43 extracted from
- Isolation, properties, and mechanism of in vitro action of lecithin: cholesterol acyltransferase from human plasma (1979), J. Biol. Chem., 254, 7456-7464.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein A-I | required for transferase and phospholipase activity | Homo sapiens | |
| apolipoprotein A-I | absolute requirement with phosphatidylcholine-cholesterol vesicles as a substrate | Homo sapiens | |
| additional information | apo-A-II, apo-C-III and apo-D inhibit activation of enzyme by apo-A-1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein A-II | - |
Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000091 | - |
apolipoprotein-A-I | - |
Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 59000 | - |
sedimentation equilibrium ultracentrifugation | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 24% carbohydrate by weight, 13 mol of mannose, 30 mol of galactose, 17 mol of glucosamine and 13 mol of sialic acid per mol of enzyme protein | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography using an anti-apolipoprotein D immunoglobulin-Sepharose column | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| 0.01 | - |
in cholesterol-lecithin vesicles activated with apolipoprotein A1, at 37°C and pH 7.1 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | phospholipase activity | Homo sapiens | ? | - |
? |  |
| additional information | lecithin-cholesterol single bilayer vesicles as substrate | Homo sapiens | ? | - |
? | |
| phosphatidylcholine + sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + sterol ester | - |
r | |
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