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Literature summary for 2.3.1.43 extracted from

  • Subbaiah, P.V.
    Lysolecithin acyltransferase of human plasma: assay and characterization of enzyme activity (1986), Methods Enzymol., 129, 790-797.
    View publication on PubMed
Search for more literature for 2.3.1.43

Activating Compound

Activating Compound Comment Organism Structure
low-density lipoprotein required for acylation of lysolecithin Homo sapiens
Serum albumin activates LCAT activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information heparin and serum albumin inhibit lysolecithin acyltransferase activity Homo sapiens
Serum albumin inhibits LAT activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 assay methods Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acylglyceryl phosphorylcholine + lecithin transfer of an acyl group from a lecithin molecule to another on the low-density lipoprotein surface, lysolecithin acyltransferase activity Homo sapiens lecithin + 1-acylglyceryl phosphorylcholine
-
 r
additional information mechanism of LAT reaction is similar to that of LCAT, probably involving an acyl-enzyme intermediate, 2-acyl isomers of lysolecithin and lysophosphatidylethanolamine can act as substrates in the LAT reaction Homo sapiens ?
-
 ?
phosphatidylcholine + sterol
-
 Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r