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Literature summary for 2.3.1.43 extracted from

  • Aron, L.; Jones, S.; Fielding, C.J.
    Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity (1978), J. Biol. Chem., 253, 7220-7226.
    View publication on PubMed
Search for more literature for 2.3.1.43

Activating Compound

Activating Compound Comment Organism Structure
albumin phospholipase activity is dependent on Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid)
-
 Homo sapiens
Ag+
-
 Homo sapiens
lysolecithin inhibition of LCAT activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information Ca2+-independent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sephadex G-100, hydroxyapatite and affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.34
-
 at 37°C in cholesterol-lecithin vesicles Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phospholipase activity Homo sapiens ?
-
 ?
phosphatidylcholine + sterol predominant but incomplete specificity for reaction at position 2 of mixed lecithins Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8 lecithin-cholesterol acyltransferase activity Homo sapiens
8
-
 phospholipase activity Homo sapiens