Literature summary for 2.3.1.41 extracted from

Moche, M.; Dehesh, K.; Edwards, P.; Lindqvist, Y.
The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54.ANG. resolution and its relationship to other condensing enzymes (2001), J. Mol. Biol., 305, 491-503.

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Application

Application	Comment	Organism
medicine	target for the development of drugs for the treatment of cancer and tuberculosis	Synechocystis sp.
nutrition	target for the engineering of plant seed oils	Synechocystis sp.
pharmacology	target for the development of drugs for the treatment of cancer and tuberculosis, involved in biosynthesis of precursors of pharmacological agents	Synechocystis sp.

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Synechocystis sp.

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method, protein solution: 25 mM Tris-HCl, pH 8.0, 300 mM NaCl, 75 mM imidazole, reservoir solution: 0.085 M tri-sodium citrate, 0.17 M ammonium acetate, 22% w/v polyethylene glycol 4000, 15% v/v glycerol as cryo-protectant, 15% w/v 1,2,3-heptanetriol, x-ray structure analysis, three-dimensional model	Synechocystis sp.

Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp.	-	isozyme II	-

Reaction

Reaction	Comment	Organism	Reaction ID
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	structure of active site, substrate binding pocket, and subunit structure in relation to substrate specificity of the 3 isozyme types	Synechocystis sp.	a
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]	active site cysteine	Synechocystis sp.	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]	-	Synechocystis sp.	3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]	-	r

Subunits

Subunits	Comment	Organism
dimer	crystal structure analysis of subunits	Synechocystis sp.

Synonyms

Synonyms	Comment	Organism
KAS	-	Synechocystis sp.
More	3 structural classes of condensing enzymes	Synechocystis sp.

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Release 2023.1 (January 2023)