Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.41 extracted from

  • Vagelos, R.P.
    Acyl group transfer (acyl carrier protein) (1973), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 8, 155-199.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol activation Escherichia coli
dithiothreitol activation Escherichia coli
EDTA activation Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation Escherichia coli
N-ethylmaleimide no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation Clostridium kluyveri
N-ethylmaleimide no inhibition of malonyl-[acyl-carrier-protein]-decarboxylation Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
2 * 35000, SDS-PAGE Escherichia coli
37000
-
2 * 37000, gel filtration after 6 M guanidinium chloride treatment Escherichia coli
66000
-
equilibrium centrifugation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Escherichia coli part of non-associated fatty acid synthase system of plants and prokaryotes 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Clostridium kluyveri part of non-associated fatty acid synthase system of plants and prokaryotes 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Escherichia coli responsible for chain elongation during de novo fatty acid synthesis 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] Clostridium kluyveri responsible for chain elongation during de novo fatty acid synthesis 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?

Organism

Organism UniProt Comment Textmining
Clostridium kluyveri
-
-
-
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] mechanism Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-CoA + [acyl-carrier protein] catalyzes fatty acyl transfer between CoA and [acyl-carrier-protein], but no direct transfer to the enzyme as with acyl-[acyl-carrier-protein] Escherichia coli acyl-[acyl-carrier protein] + CoA
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] part of non-associated fatty acid synthase system of plants and prokaryotes Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] part of non-associated fatty acid synthase system of plants and prokaryotes Clostridium kluyveri 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] responsible for chain elongation during de novo fatty acid synthesis Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] responsible for chain elongation during de novo fatty acid synthesis Clostridium kluyveri 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
cis-9-hexadecenoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxo-cis-11-octadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Clostridium kluyveri cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
cis-mono-unsaturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] not cis-vaccenoyl-[acyl-carrier-protein], i.e. cis-11-octenoyl-[acyl-carrier-protein] Escherichia coli cis-mono-unsaturated 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
malonyl-[acyl-carrier protein] decarboxylation with 2-3% the rate of beta-ketoacyl-[acyl-carrier-protein]-synthesis Escherichia coli acetyl-[acyl-carrier protein] + CO2
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Clostridium kluyveri 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] substrate specificity, overview Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] not hexadecanoyl-[acyl-carrier-protein] Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] specific for acyl-[acyl-carrier-protein] thioesters, not acyl-CoA or acyl pantetheine thioesters Escherichia coli 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
tetradecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Escherichia coli 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?

Subunits

Subunits Comment Organism
dimer 2 * 35000, SDS-PAGE Escherichia coli
dimer 2 * 37000, gel filtration after 6 M guanidinium chloride treatment Escherichia coli
More vertebrates, yeast and Mycobacteria fatty acid synthetases contain all individual activities on one or two multifunctional polypeptide chains, plant, Escherichia coli and other prokaryotic fatty acid synthases are non-associated systems of individual enzymes Escherichia coli
More vertebrates, yeast and Mycobacteria fatty acid synthetases contain all individual activities on one or two multifunctional polypeptide chains, plant, Escherichia coli and other prokaryotic fatty acid synthases are non-associated systems of individual enzymes Clostridium kluyveri

Synonyms

Synonyms Comment Organism
More in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86 Escherichia coli
More in vertebrates, yeast and Mycobacteria beta-ketoacyl synthase activity is a domain of the multifunctional polypeptide chains of fatty acid synthase EC 2.3.1.85 and EC 2.3.1.86 Clostridium kluyveri

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.8
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8
-
Escherichia coli