Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.4 extracted from

  • Cova, M.; Lopez-Gutierrez, B.; Artigas-Jeronimo, S.; Gonzalez-Diaz, A.; Bandini, G.; Maere, S.; Carretero-Paulet, L.; Izquierdo, L.
    The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene family encodes a key enzyme for glycoconjugate synthesis with potential as therapeutic target (2018), Sci. Rep., 8, 4005 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.4

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: spermine nor spermidine Toxoplasma gondii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.241
-
 acetyl-CoA pH not specified in the publication, temperature not specified in the publication Cryptosporidium parvum
0.719
-
 D-glucosamine 6-phosphate pH not specified in the publication, temperature not specified in the publication Cryptosporidium parvum

Organism

Organism UniProt Comment Textmining
Cryptosporidium parvum Q5CPU3
-
-
Cryptosporidium parvum Iowa II Q5CPU3
-
-
Plasmodium falciparum C6KTC5
-
-
Toxoplasma gondii S7UFV0
-
-
Toxoplasma gondii ATCC 50853 S7UFV0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + D-glucosamine 6-phosphate
-
 Plasmodium falciparum CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
acetyl-CoA + D-glucosamine 6-phosphate
-
 Cryptosporidium parvum CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
acetyl-CoA + D-glucosamine 6-phosphate
-
 Toxoplasma gondii CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
acetyl-CoA + D-glucosamine 6-phosphate
-
 Toxoplasma gondii ATCC 50853 CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
acetyl-CoA + D-glucosamine 6-phosphate
-
 Cryptosporidium parvum Iowa II CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
additional information enzyme is not able to acetylate spermine or spermidine Cryptosporidium parvum ?
-
-
additional information enzyme is not able to acetylate spermine or spermidine Cryptosporidium parvum Iowa II ?
-
-

Synonyms

Synonyms Comment Organism
cgd4_4000
-
 Cryptosporidium parvum
GNA1
-
 Plasmodium falciparum
GNA1
-
 Cryptosporidium parvum
GNA1
-
 Toxoplasma gondii
PF3D7_0629000
-
 Plasmodium falciparum
TGGT1_243600
-
 Toxoplasma gondii

General Information

General Information Comment Organism
physiological function the GNA1 gene plays an essential role for the survival of the parasite, least during Plasmodium falciparum asexual blood stages Plasmodium falciparum