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Literature summary for 2.3.1.39 extracted from

  • Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P.
    Biophysical and in silico interaction studies of aporphine alkaloids with malonyl-CoA ACP transacylase (FabD) from drug resistant Moraxella catarrhalis (2018), Biochimie, 149, 18-33 .
    View publication on PubMed
Search for more literature for 2.3.1.39

Application

Application Comment Organism
drug development the enzyme is a target for developing broad-spectrum antibiotics Moraxella catarrhalis

Inhibitors

Inhibitors Comment Organism Structure
apomorphine
-
 Moraxella catarrhalis
boldine
-
 Moraxella catarrhalis
corytuberine
-
 Moraxella catarrhalis
magnoflorine
-
 Moraxella catarrhalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malonyl-CoA + an [acyl-carrier protein] Moraxella catarrhalis
-
 CoA + a malonyl-[acyl-carrier protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Moraxella catarrhalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonyl-CoA + an [acyl-carrier protein]
-
 Moraxella catarrhalis CoA + a malonyl-[acyl-carrier protein]
-
 ?

Synonyms

Synonyms Comment Organism
FabD
-
 Moraxella catarrhalis
malonyl-CoA:ACP transacylase
-
 Moraxella catarrhalis

General Information

General Information Comment Organism
metabolism the enzyme is an essential enzyme of the fatty acid synthesis II pathway. It performs initiation reaction to form malonyl-ACP, which is a key building block in fatty acid biosynthesis. Aporphine alkaloids can act as antibacterial agents and possible target of these compounds could be the FabD enzyme Moraxella catarrhalis