Literature summary for 2.3.1.39 extracted from

Paiva, P.; Sousa, S.; Ramos, M.; Fernandes, P.
Understanding the catalytic machinery and the reaction pathway of the malonyl-acetyl transferase domain of human fatty acid synthase (2018), ACS Catal., 8, 4860-4872 .

No PubMed abstract available

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Protein Variants

Protein Variants	Comment	Organism
R606A	the mutation severely impairs the malonyl transfer reaction, while leading to a kinetic improvement of the transferase activity for acetyl-CoA	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + an [acyl-carrier protein]	Homo sapiens	-	CoA + an acetyl-[acyl-carrier protein]	-	?
malonyl-CoA + an [acyl-carrier protein]	Homo sapiens	-	CoA + a malonyl-[acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49327	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + an [acyl-carrier protein]	-	Homo sapiens	CoA + an acetyl-[acyl-carrier protein]	-	?
malonyl-CoA + an [acyl-carrier protein]	-	Homo sapiens	CoA + a malonyl-[acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
FAS	-	Homo sapiens
fatty acid synthase	-	Homo sapiens
MAT	malonyl-acetyl transferase domain of fatty acid synthase	Homo sapiens

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Release 2023.1 (January 2023)