Literature summary for 2.3.1.39 extracted from

Hoenke, S.; Dimroth, P.
Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected] (1999), Eur. J. Biochem., 259, 181-187.

Search for more literature for 2.3.1.39

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.016	-	malonyl-CoA	pH 7.5, 37°C	Klebsiella pneumoniae
0.016	-	methylmalonyl-CoA	pH 7.5, 37°C	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	O32717	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
malonyl-CoA + acyl-carrier protein	-	Klebsiella pneumoniae	CoA + malonyl-[acyl-carrier protein]	-	?
methylmalonyl-CoA + acyl-carrier protein	-	Klebsiella pneumoniae	CoA + methylmalonyl-[acyl-carrier protein]	-	?
additional information	presence of malonyl-CoA:ACP transacylase MdcH is required for catalytic activity of malonate decarboxylase. Substrates for MdcH are malonyl-CoA or methylmalonyl-CoA but not acetyl-CoA. Transfer of the methylmalonyl-residue to the prosthetic group proceeds via the covalent methylmalonyl-MdcH intermediate	Klebsiella pneumoniae	?	-	?

Subunits

Subunits	Comment	Organism
tetramer	malonate decarboxylase consists of the four subunits MdcA, MdcD, MdcE and MdcC in an apparent 1:1:1:1 stoichiometry. The preparation contains substoichiometric amounts of malonyl-CoA:ACP transacylase MdcH comigrating on SDS/PAGE with MdcD	Klebsiella pneumoniae

Synonyms

Synonyms	Comment	Organism
MdcH	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)