Literature summary for 2.3.1.37 extracted from

Barman-Aksoezen, J.; Halloy, F.; Iyer, P.S.; Schuemperli, D.; Minder, A.E.; Hall, J.; Minder, E.I.; Schneider-Yin, X.
Delta-aminolevulinic acid synthase 2 expression in combination with iron as modifiers of disease severity in erythropoietic protoporphyria (2019), Mol. Genet. Metab., 128, 304-308 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + glycine	Homo sapiens	-	5-aminolevulinate + CoA + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22557	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythroid cell	-	Homo sapiens	-
K-562 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + glycine	-	Homo sapiens	5-aminolevulinate + CoA + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ALAS2	-	Homo sapiens
aminolevulinic acid synthase 2	-	Homo sapiens
delta-aminolevulinic acid synthase 2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	elevated mRNA and protein levels of isoform ALAS2 are observed among patients with erythropoietic protoporphyria. Iron deprivation increases the amount of isoform ALAS2 mRNA	up

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Release 2023.1 (January 2023)