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Literature summary for 2.3.1.37 extracted from

  • Stojanovski, B.M.; Hunter, G.A.; Na, I.; Uversky, V.N.; Jiang, R.H.Y.; Ferreira, G.C.
    5-Aminolevulinate synthase catalysis The catcher in heme biosynthesis (2019), Mol. Genet. Metab., 128, 178-189 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.37

Protein Variants

Protein Variants Comment Organism
K221V the mutant shows severely reduced catalytic efficiency towards succinyl-CoA compared to the wild type enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Mus musculus
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P08680
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroid cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with L-alanine, L-serine or L-threonine Mus musculus ?
-
-
succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
ALAS2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus