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Literature summary for 2.3.1.37 extracted from
- Hypothesis Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias (2019), Med. Hypotheses, 131, 109314 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| carbamazepine | - |
Rattus norvegicus |  |
| estrogen | - |
Rattus norvegicus | |
| ethanol | - |
Rattus norvegicus | |
| ethinylestradiol | - |
Rattus norvegicus | |
| norethandrolone | - |
Rattus norvegicus | |
| Norethindrone | - |
Rattus norvegicus | |
| Phenobarbitone | - |
Rattus norvegicus | |
| Phenylbutazone | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetate | - |
Rattus norvegicus | |
| adrenaline | - |
Rattus norvegicus | |
| allopurinol | - |
Rattus norvegicus | |
| aspirin | - |
Rattus norvegicus | |
| Benserazide | - |
Rattus norvegicus | |
| chlorpromazine | - |
Rattus norvegicus | |
| estradiol | - |
Rattus norvegicus | |
| estrogen | - |
Rattus norvegicus | |
| fluoxetine | - |
Rattus norvegicus | |
| heme | - |
Rattus norvegicus | |
| lithium | - |
Rattus norvegicus | |
| morphine | - |
Rattus norvegicus | |
| naloxone | - |
Rattus norvegicus | |
| noradrenaline | - |
Rattus norvegicus | |
| paroxetine | - |
Rattus norvegicus | |
| progesterone | - |
Rattus norvegicus | |
| progestogen | - |
Rattus norvegicus | |
| propranolol | - |
Rattus norvegicus | |
| tryptophan | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + glycine | Rattus norvegicus | - |
5-aminolevulinate + CoA + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + glycine | - |
Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-ALA synthase | - |
Rattus norvegicus |
| 5-ALAS | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | fasting (starvation) induces enzyme activity. Griseofulvin induces enzyme mRNA expression after 2 days of treatment | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | rate-limiting enzyme of heme biosynthesis | Rattus norvegicus |
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