Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1-Dimethylhydrazine | about 75% residual activity at 0.01 mM | Homo sapiens | |
isoniazid | about 25% residual activity at 0.01 mM. Isoniazid directly inhibits the enzyme, noncompetitively or uncompetitively. about 0.4 mM pyridoxal 5'-phosphate and PMP reduce the effect of isoniazid on isoform ALAS2 inhibition | Homo sapiens | |
Pyrazinamide | about 85% residual activity at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | Homo sapiens | - |
5-aminolevulinate + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22557 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity chromatography column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroid cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 57300, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ALAS2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
isoniazid | apparent value, pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutations are associated with two different blood disorders, X-linked sideroblastic anemia and X-linked protoporphyria | Homo sapiens |