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Literature summary for 2.3.1.37 extracted from

  • Lake-Bullock, H.; Dailey, H.A.
    Biphasic ordered induction of heme synthesis in differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate synthase (1993), Mol. Cell. Biol., 13, 7122-7132.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.37

Activating Compound

Activating Compound Comment Organism Structure
Butyric acid induction of enzyme expression, erythroleukemia cells Mus musculus
Dimethylsulfoxide induction of enzyme expression, erythroleukemia cells Mus musculus
hexamethylene diacetamide induction of enzyme expression, erythroleukemia cells Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information stable MEL mutant, no induction of enzyme expression by dimethylsulfoxide, hexamethylene diacetamide and butyric acid, decline of enzyme activity after DMSO application Mus musculus
additional information expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor results in induction of enzyme activity by addition of Zn2+ and Cd2+ in absence of DMSO Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Mus musculus cellular iron status plays a regulatory role 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine Mus musculus rate-limiting enzyme of heme biosynthesis 5-aminolevulinate + CoA + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 inducible in erythroleukemia cells
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell line erythroid-specific isoform Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine cellular iron status plays a regulatory role Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
succinyl-CoA + glycine rate-limiting enzyme of heme biosynthesis Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus