Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hemin | - |
Cavia porcellus | |
hemin | feed-back inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | 0.01 | pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
0.2 | - |
succinyl-CoA | - |
Rattus norvegicus | |
19 | - |
glycine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
mitochondrion | - |
Cavia porcellus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
additional information | - |
Cavia porcellus | - |
- |
additional information | processing of enzyme during to targeting to subcellular compartments | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
77000 | - |
mitochondria, gel filtration | Rattus norvegicus |
178000 | - |
cytosol, gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Rattus norvegicus | - |
2 isoforms in cytosol and mitochondria | - |
Purification (Comment) | Organism |
---|---|
- |
Cavia porcellus |
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Cavia porcellus | - |
liver | porphyric | Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
-15°C, loss of 25% activity within 10 days | Rattus norvegicus |
4°C, loss of 40% activity within 10 days | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Cavia porcellus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | - |
Rattus norvegicus | 5-aminolevulinate + CoA + CO2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Cavia porcellus | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus |