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Literature summary for 2.3.1.37 extracted from
- delta-Aminolevulinic acid synthetase of Rhodopseudomonas spheroides: purification and properties of the enzyme (1972), Arch. Biochem. Biophys., 150, 77-85.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | required | Cereibacter sphaeroides |  |
General Stability
| General Stability | Organism |
|---|---|
| freezing and thawing: precipitation and loss of activity | Cereibacter sphaeroides |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | - |
Cereibacter sphaeroides | |
| Cu2+ | at low concentration | Cereibacter sphaeroides | |
| Fe2+ | - |
Cereibacter sphaeroides | |
| Fe3+ | slight | Cereibacter sphaeroides | |
| hemin | - |
Cereibacter sphaeroides | |
| Hg2+ | 2-mercaptoethanol protects partly | Cereibacter sphaeroides | |
| iodoacetamide | - |
Cereibacter sphaeroides | |
| Mg-protoporphyrin | - |
Cereibacter sphaeroides | |
| N-ethylmaleimide | 2-mercaptoethanol protect | Cereibacter sphaeroides | |
| p-chloromercuribenzoate | 2-mercaptoethanol protect partly | Cereibacter sphaeroides | |
| protoporphyrin | weak | Cereibacter sphaeroides | |
| Zn2+ | - |
Cereibacter sphaeroides | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 61000 | - |
gel filtration | Cereibacter sphaeroides |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cereibacter sphaeroides | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cereibacter sphaeroides |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.558 | - |
purified enzyme | Cereibacter sphaeroides |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 5°C, 50 mM phosphate buffer, pH 7.2, 10 mM 2-mercaptoethanol, 20% loss of activity after 1 week | Cereibacter sphaeroides |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + glycine | - |
Cereibacter sphaeroides | 5-aminolevulinate + CoA + CO2 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
- |
Cereibacter sphaeroides |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Cereibacter sphaeroides | |
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Release 2023.1 (January 2023)
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