Literature summary for 2.3.1.37 extracted from

Nandi, D.L.
Studies on delta-aminolevulinic acid synthase of Rhodopseudomonas spheroides. Reversibility of the reaction, kinetic, spectral, and other studies related to the mechanism of action (1978), J. Biol. Chem., 253, 8872-8877.

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Inhibitors

Inhibitors	Comment	Organism	Structure
aminomalonate	competitive versus glycine	Cereibacter sphaeroides
Aminomethylphosphonate	-	Cereibacter sphaeroides
Borohydride	aminomalonate protects; in presence of pyridoxal 5'-phosphate	Cereibacter sphaeroides
additional information	product inhibition pattern for the forward reaction and the reverse reaction	Cereibacter sphaeroides

Organism

Organism	UniProt	Comment	Textmining
Cereibacter sphaeroides	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2	mechanism	Cereibacter sphaeroides	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + glycine	glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions	Cereibacter sphaeroides	5-aminolevulinate + CoA + CO2	-	r

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Cereibacter sphaeroides

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.023	-	aminomalonate	-	Cereibacter sphaeroides
10	-	Aminomethylphosphonate	-	Cereibacter sphaeroides

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Release 2023.1 (January 2023)