Literature summary for 2.3.1.305 extracted from

Robins, L.; Williams, A.; Raetz, C.
Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA (2009), Biochemistry, 48, 6191-6201 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structures of free LpxA and its complexes with its product UDP-3-N-(R-3-hydroxylauroyl)-GlcNAc3N and with its substrate R-3-hydroxylauroyl-methylphosphopantetheine. The selectivity of LiLpxA for UDPGlcNAc3N may be explained by the orientation of the backbone carbonyl group of Q68, which differs by about 82° from the corresponding Q73 carbonyl group in Escherichia coli LpxA. The R-3-hydroxylauroyl selectivity of LpxA is explained by the position of the K171 side chain, which limits the length of the acyl-chain-binding groove	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV

Crystallization (Comment)

Organism

structures of free LpxA and its complexes with its product UDP-3-N-(R-3-hydroxylauroyl)-GlcNAc3N and with its substrate R-3-hydroxylauroyl-methylphosphopantetheine. The selectivity of LiLpxA for UDPGlcNAc3N may be explained by the orientation of the backbone carbonyl group of Q68, which differs by about 82° from the corresponding Q73 carbonyl group in Escherichia coli LpxA. The R-3-hydroxylauroyl selectivity of LpxA is explained by the position of the K171 side chain, which limits the length of the acyl-chain-binding groove

Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV

Organism

Organism	UniProt	Comment	Textmining
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV	Q8EZA6	-	-
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV 56601	Q8EZA6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(3R)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose	-	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV	acyl-carrier protein + UDP-2-acetamido-2,3-dideoxy-3-[[(3R)-3-hydroxylauroyl]amino]-alpha-D-glucopyranose	-	?
(3R)-3-hydroxylauroyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose	-	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV 56601	acyl-carrier protein + UDP-2-acetamido-2,3-dideoxy-3-[[(3R)-3-hydroxylauroyl]amino]-alpha-D-glucopyranose	-	?

Synonyms

Synonyms	Comment	Organism
LpxA	-	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai IPAV