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Literature summary for 2.3.1.298 extracted from

  • Ferreira, N.S.; Engelsby, H.; Neess, D.; Kelly, S.L.; Volpert, G.; Merrill, A.H.; Futerman, A.H.; Faergeman, N.J.
    Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein (2017), J. Biol. Chem., 292, 7588-7597 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.298

Activating Compound

Activating Compound Comment Organism Structure
acyl-coenzyme A-binding protein increases the activity of the enzyme by 7fold Mus musculus
additional information high-speed liver cytosol from wild type mice activates enzyme activity, whereas cytosol from acyl-coenzyme A-binding protein knock-out mice does not Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
W15R catalytically inactive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base Mus musculus
-
 an ultra-long-chain ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain fatty acyl-CoA + a sphingoid base
-
 Mus musculus an ultra-long-chain ceramide + CoA
-
 ?
hexacosanoyl-CoA + sphinganine main substrate Mus musculus hexacosanoyl ceramide + CoA
-
 ?

Synonyms

Synonyms Comment Organism
CerS3
-
 Mus musculus
sphingoid base N-ultra-long-chain fatty acyl-coA transferase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme activity is significantly reduced in the testes of acyl-coenzyme A-binding protein-deficient mice down