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Literature summary for 2.3.1.298 extracted from

  • Mizutani, Y.; Kihara, A.; Igarashi, Y.
    LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity (2006), Biochem. J., 398, 531-538 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.298

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
fumonisin B1
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fatty acyl-CoA + dihydrosphingosine Mus musculus
-
 ceramide + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q1A3B0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis enzyme expression is limited almost solely to testis Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidoyl-CoA + dihydrosphingosine weak activity Mus musculus CoA + N-arachidoyl-dihydrosphingosine
-
 ?
behenoyl-CoA + dihydrosphingosine
-
 Mus musculus CoA + N-behenoyldihydrosphingosine
-
 ?
cerotoyl-CoA + dihydrosphingosine weak activity Mus musculus CoA + N-cerotoyl-dihydrosphingosine
-
 ?
fatty acyl-CoA + dihydrosphingosine
-
 Mus musculus ceramide + CoA
-
 ?
lignoceroyl-CoA + dihydrosphingosine
-
 Mus musculus CoA + N-lignoceroyldihydrosphingosine
-
 ?
additional information the enzyme exhibits relatively low substrate specificity toward fatty-acyl CoAs Mus musculus ?
-
 ?
palmitoyl-CoA + dihydrosphingosine high activity Mus musculus CoA + N-palmitoyldihydrosphingosine
-
 ?
stearoyl-CoA + dihydrosphingosine highest activity Mus musculus CoA + N-stearoyldihydrosphingosine
-
 ?

Synonyms

Synonyms Comment Organism
(dihydro)ceramide synthase
-
 Mus musculus
LASS3 gene name, longevity assurance homologue 3 Mus musculus
LASS3-long transcriptional variant Mus musculus