Literature summary for 2.3.1.297 extracted from

Berdyshev, E.V.; Gorshkova, I.; Skobeleva, A.; Bittman, R.; Lu, X.; Dudek, S.M.; Mirzapoiazova, T.; Garcia, J.G.; Natarajan, V.
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells (2009), J. Biol. Chem., 284, 5467-5477 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
FTY720	FTY720 is an effective immunomodulatory molecule and is a competitive inhibitor of ceramide synthase 2 toward dihydrosphingosine, it shows interference with sphingolipid de novo biosynthesis, overview. The inhibition of CerS2 activity is reversible as the potency of inhibition diminishes with the dilution of the enzyme-inhibitor preparation	Homo sapiens
fumonisin B1	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0000677	-	behenoyl-CoA	pH 7.4, 37°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Homo sapiens	-
pulmonary artery endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-erythro-sphinganine + behenoyl-CoA	-	Homo sapiens	N-behenoyl-D-sphinganine + CoA	-	?

Synonyms

Synonyms	Comment	Organism
ceramide synthase 2	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00215	-	FTY720	pH 7.4, 37°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0064	-	pH 7.4, 37°C	Homo sapiens	FTY720

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Release 2023.1 (January 2023)