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Literature summary for 2.3.1.295 extracted from

  • Matsunaga, I.; Bhatt, A.; Young, D.C.; Cheng, T.Y.; Eyles, S.J.; Besra, G.S.; Briken, V.; Porcelli, S.A.; Costello, C.E.; Jacobs, W.R.; Moody, D.B.
    Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells (2004), J. Exp. Med., 200, 1559-1569 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli HB101 cells Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
430000
-
gel filtration Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ Mycobacterium tuberculosis
-
a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
-
?
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+ Mycobacterium tuberculosis H37Rv
-
a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+
-
Mycobacterium tuberculosis a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
-
?
a medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH + 22 H+
-
Mycobacterium tuberculosis H37Rv a mycoketide-CoA + 10 CO2 + 10 CoA + 22 NADP+ + 11 H2O
-
?

Synonyms

Synonyms Comment Organism
pks12
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme is necessary for antigen production, but did not affect synthesis of true isoprenols Mycobacterium tuberculosis