Literature summary for 2.3.1.294 extracted from

Bhatt, A.; Fujiwara, N.; Bhatt, K.; Gurcha, S.S.; Kremer, L.; Chen, B.; Chan, J.; Porcelli, S.A.; Kobayashi, K.; Besra, G.S.; Jacobs, W.R.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice (2007), Proc. Natl. Acad. Sci. USA, 104, 5157-5162 .

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Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-acyl carrier protein synthase	-	Mycobacterium tuberculosis
KasB	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
malfunction	enzyme gene deletion in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. An additional outcome of enzyme gene deletion is the loss of ketomycolic acid trans-cyclopropanation and a drastic reduction in methoxymycolic acid trans-cyclopropanation. Although deletion of the enzyme also markedly alters the colony morphology and abolishes classic serpentine growth (cording), the most profound effect of enzyme gene deletion is the ability of the mutant strain to persist in infected immunocompetent mice for up to 600 days without causing disease or mortality	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)