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Literature summary for 2.3.1.294 extracted from

  • Bhatt, A.; Molle, V.; Besra, G.; Jacobs Jr., W.; Kremer, L.
    The Mycobacterium tuberculosis FAS-II condensing enzymes Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development (2007), Mol. Microbiol., 64, 1442-1454 .
    View publication on PubMed
Search for more literature for 2.3.1.294

Inhibitors

Inhibitors Comment Organism Structure
n-octanesulfonylacetamide
-
 Mycobacterium tuberculosis
thiolactomycin
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein transphosphorylation increases the enzyme activity Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
an ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl AcpM synthase
-
 Mycobacterium tuberculosis
KasB
-
 Mycobacterium tuberculosis
Rv2246
-
 Mycobacterium tuberculosis

Expression

Organism Comment Expression
Mycobacterium tuberculosis the enzyme is up-regulated under aerobic conditions up

General Information

General Information Comment Organism
physiological function the enzyme is involved in cording and acid-fast staining and is required for survival and virulence in infected mice Mycobacterium tuberculosis