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Literature summary for 2.3.1.293 extracted from

  • Kremer, L.; Douglas, J.D.; Baulard, A.R.; Morehouse, C.; Guy, M.R.; Alland, D.; Dover, L.G.; Lakey, J.H.; Jacobs, W.R.; Brennan, P.J.; Minnikin, D.E.; Besra, G.S.
    Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis (2000), J. Biol. Chem., 275, 16857-16864 .
    View publication on PubMed
Search for more literature for 2.3.1.293

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mycobacterium bovis BCG vaccine strain 1173P2 Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
G269S the S mutation may affect targeting of the inhibitor thiolactomycin to the enzyme Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
thiolactomycin
-
 Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mycobacterium tuberculosis 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycobacterium tuberculosis the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids ?
-
 ?
additional information Mycobacterium tuberculosis H37Rv the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids Mycobacterium tuberculosis ?
-
 ?
additional information the enzyme catalyzes the condensation steps from C18 to C34 long-chain fatty acids Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

Subunits Comment Organism
? x * 43000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl-carrier protein synthase
-
 Mycobacterium tuberculosis
KasA
-
 Mycobacterium tuberculosis
Rv2245
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme is involved in fatty acid and mycolic acid biosynthesis Mycobacterium tuberculosis