Literature summary for 2.3.1.29 extracted from

Zhang, L.; Cao, Y.; Tong, J.; Xu, Y.
An alkylpyrazine synthesis mechanism involving L-threonine-3-dehydrogenase describes the production of 2,5-dimethylpyrazine and 2,3,5-trimethylpyrazine by Bacillus subtilis (2019), Appl. Environ. Microbiol., 85, e01807 .

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Application

Application	Comment	Organism
synthesis	enzyme is applied in synthesis of 2,5-dimethylpyrazine. Bacillus subtilis can synthesize 2,5-dimethylpyrazine by using L-threonine as the substrate via aminoacetone. The reaction from L-threonine to L-2-amino-acetoacetate is catalyzed by L-threonine-3-dehydrogenase. L-2-Amino-acetoacetate can spontaneously decarboxylate to form aminoacetone. The reaction from aminoacetone to 2,5-dimethylpyrazine is a pH-dependent nonenzymatic reaction. Inactivation of 2-amino-3-ketobutyrate CoA ligase improves 2,5-dimethylpyrazine production	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Bacillus subtilis 168	-	-	-

Synonyms

Synonyms	Comment	Organism
KBL	-	Bacillus subtilis

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Release 2023.1 (January 2023)