Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.286 extracted from

  • Kang, W.K.; Devare, M.; Kim, J.Y.
    HST1 increases replicative lifespan of a sir2DELTA mutant in the absence of PDE2 in Saccharomyces cerevisiae (2017), J. Microbiol., 55, 123-129 .
    View publication on PubMed
Search for more literature for 2.3.1.286

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Saccharomyces cerevisiae BY4741
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O overall reaction Saccharomyces cerevisiae [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O overall reaction Saccharomyces cerevisiae BY4741 [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
-
 Saccharomyces cerevisiae BY4741 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
Hst1
-
 Saccharomyces cerevisiae
silent information regulator 2
-
 Saccharomyces cerevisiae
Sir2
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme is a pro-longevity factor for replicative lifespan in Saccharomyces cerevisiae. The enzyme is required for transcriptional silencing at mating type loci, telomeres, and rDNA loci. The enzyme also represses transcription of highly expressed growth-related genes, such as PMA1 and some ribosomal protein genes Saccharomyces cerevisiae