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Literature summary for 2.3.1.286 extracted from

  • Cen, Y.; Sauve, A.A.
    Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches (2010), J. Am. Chem. Soc., 132, 12286-12298 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Inhibitors

Inhibitors Comment Organism Structure
nicotinamide
-
 Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[protein]-N6-acetyl-L-lysine + NAD+ Archaeoglobus fulgidus
-
 [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O Archaeoglobus fulgidus overall reaction [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O Archaeoglobus fulgidus
-
 [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HLKSKKGQSTSRHK(K-Ac)LMFK + NAD+ + H2O p53A peptide Archaeoglobus fulgidus HLKSKKGQSTSRHKKLMFK + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+
-
 Archaeoglobus fulgidus [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
-
 ?
[protein]-N6-acetyl-L-lysine + NAD+ + H2O overall reaction Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
-
 Archaeoglobus fulgidus [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
Af2Sir2
-
 Archaeoglobus fulgidus
Sir2
-
 Archaeoglobus fulgidus
sirtuin
-
 Archaeoglobus fulgidus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Archaeoglobus fulgidus