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Literature summary for 2.3.1.286 extracted from

  • Buscaino, A.; Lejeune, E.; Audergon, P.; Hamilton, G.; Pidoux, A.; Allshire, R.C.
    Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance (2013), EMBO J., 32, 1250-1264 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[histone H3]-N6-acetyl-L-lysine9 + NAD+ + H2O overall reaction Schizosaccharomyces pombe [histone H3]-L-lysine9 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
Clr3
-
 Schizosaccharomyces pombe
HDAC
-
 Schizosaccharomyces pombe
histone deacetylase
-
 Schizosaccharomyces pombe
Sir2
-
 Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
physiological function maintenance of [histone H3]-L-lysine9 methylation at centromeres requires the histone deacetylases Sir2 and Clr3 Schizosaccharomyces pombe